Shami (Prosopis cineraria (L) Druce) belongs to family Fabaceae known for its spiritual uses in India mentioned in almost all the Nighantu’s of Ayurveda. It is endemic to Hot, Dry and Arid regions of India. Even though almost all the parts of Shami are having pharmacological actions specially the Bark and Fruit but these remain unexplored. It mainly contains tannins (gallic acid), alkaloids (spicigerine, prosophylline), Flavone derivatives (prosogerin A, B, C, D and E) and quercetin are widely used as anti-oxidant, anti-microbial, anti-bacterial, anti-convulsant, nootropic and antidepressant activity. Thus, the current article reviews on Ayurveda literature, botanical description, varieties and powder microscopy of Shami
