This is a single case study that investigated brain connectivity (coherence) using Magnetoencephalography (MEG) in a twenty-four-year-old male who underwent hand transplantation of his right hand at 18 months after a traumatic injury. We examined the neuromagnetic fields of the whole brain during resting state. There is little research on brain reorganization and connectivity within the brain following transplantation, specifically, during resting state. Our findings revealed increased coherence within sensory cortices of the Default Mode Network (DMN) during the early phase of recovery while enhanced coherence in motor cortical regions became apparent in the later phase of recovery