Preceptors play a vital role in supporting nursing/midwifery students and new employees’ transition and assimilation into their new role. Furthermore, with the increasing focus on educating more qualified nurses and midwives to meet health-related United Nations Sustainable Development Goals, there is a need for a more standardized and coordinated approach to preceptorship training. As former Head of the Nursing/Midwifery Training Institution in Ghana, I observed first-hand that the system of preceptorship needs improvements. Published literature on preceptorship has shown that the practice plays a vital role in healthcare delivery. However, most of the existing literature preceptorship is from developed countries, with little research from developing countries like Ghana. This study explored the practice of preceptorship in selected nursing/midwifery and healthcare institutions in Ghana. Situational analysis was used to examine the complex dynamics of the preceptorship program. It consists of three main procedural tools: situational maps, social worlds/arenas maps, and positional maps. Several important factors were found to impact preceptorship in Ghana. Key ones were motivational (monetary) challenges, lack of training of preceptors, politicking related to the development of preceptorship manuals, supervision, and outdated procedure guidelines for on-the-job teaching students. The study offers a series of recommendations to improve preceptorship practice at micro, meso, and macro levels. Additionally, they may enable regulators and policy makers in Ghana to formulate policies leading to a more robust preceptorship program to strengthen the skills of nursing/midwifery profession. This dissertation is available in open access at AURA (https://aura.antioch.edu) and OhioLINK ETD Center (https://etd.ohiolink.edu)