The liver is a vital organ of the human body andhepatic cancer is one of the major causes of cancer deaths. Earlyand rapid diagnosis can reduce the mortality rate. It can beachieved through computerized cancer diagnosis and surgeryplanning systems. Segmentation plays a major role in thesesystems. This work evaluated the efficacy of the SegNet model inliver and particle swarm optimization-based clustering techniquein liver lesion segmentation. The method was evaluated on portalvenous phase CT images obtained from ten patients at KasturbaHospital, Manipal. The segmentation results were satisfactory.The values for Dice Coefficient and volumetric overlap errorachieved were 0.940 ± 0.022 and 0.112 ± 0.038, respectively forliver and the results for lesion delineation were 0.4629 ± 0.287and 0.6986 ± 0.203, respectively. The proposed method is effectivefor liver segmentation. However, lesion segmentation needs to befurther improved for better accuracy
