Experimental evaluation of synergism of cisplatin with L-lysine-α- oxidase

Abstract

Synergism effects of cisplatin and L-lysine-α-oxidase (LO), while sequential (no interval) administration of drugs depends on the tumor model and duration of treatment. Synergism is identified at intraperitoneal daily (during 3 days) administration of cisplatin to experimental animals in single doses of 1.5 or 3.0 mg / kg and intravenously 5-fold after 48 h administration of LO and also administered intravenously in cumulative doses of 300-600 E / kg discretely, the first dose - doubled. Synergism of cisplatin and LO is showed by significant (p<0,05) therapeutic gain against cisplatin at such indicators as increased survival of mice with P388 tumor and increased inhibition of primary tumor melanoma B16