MTHFR 677CT POLYMORPHISM AND CLEFT LIP AND PALATE ANOMALIES

Abstract

A sufficient bioavailability of active folate seems to be important for normal early development of the embryo. Maternal folate insufficiency has been found more frequently in spina bifida and nonsyndromic cleft lip and/or palate (NCLP). It may be due to a mutation of a folate pathway gene or a low dietary intake