503-507A simple and efficient route has been developed for enantioselective synthesis of hyperparathyroidism agent (R)-Cinacalcet.
The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed
in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive
amination