399-404A total of fifty pyrazolines 3a-y and pyrazoles 4a-y have been evaluated for their free-radical scavenging and
α-glucosidase inhibitory activities. The pyrazolines 3e, 3h, 3p, 3s and pyrazole 4e have been identified as potent ABTS.+
free-radical scavengers. The thiophene substituted pyrazoline 3s has shown potent ABTS.+ free radical scavenging activity
compared to thiophene substituted pyrazole 4s. Furanyl (4r), pyrazolyl (4t), 2-chloropyridinyl (4u-w), 2-chloroquinolinyl
(4x) and 4-chlorocoumarin (4y) pyrazoles have displayed moderate ABTS.+ free-radical scavenging activity. Pyrazoline 3i
and pyrazole 4b have shown moderate DPPH free-radical scavenging activity