Objective: To investigate the efficacy of a single intravenous injection of oxycodone hydrochloride in patients undergoing laparoscopic rectal tumor resection with acute postoperative pain and evaluate the quality of Anesthesia recovery period. Methods: 60 patients for laparoscopic rectal tumor resection, were randomly divided into two groups (n=30 each): oxycodone hydrochloride injection group (group I) and fentanil injection group (group II). oxycodone 0.05mg / kg (saline dilution of 1mg / ml) or fentanil 0.1ug / kg was injected intravenously at the end of surgery. Assessing the OAA / S sedation grade and Prince-Henry postoperative pain scores. Results: Demographic data and anesthesia characteristics were similar in the two groups. Group II’s Prince-Henry pain score was significantly higher than the group I’s (P <0.01). Conclusion: xycodone injection can reduce the incidence of acute pain after Laparoscopic rectal tumor resection, and effectively relieve the occurred acute pain, the clinical use of oxcodone is safe and effective
