The nanofabrication of large-area metasurfaces with tunable optoelectronic response is crucial in many fields from plasmonics to energy conversion. Here the engineering of self-organized plasmonic antennas will be demonstrated, showing their performances in photo-degradation of polluting molecules. In parallel, the capability to strongly couple light to large-area 2D semiconductor layers will be shown. Thanks to nanoscale re-shaping of the interface to form flat-optics nanogratings superior photon harvesting performances can be achieved with strong impact in photonics and energy conversion.