In spatial econometrics, we usually assume that the spatial dependence structure is known and that all information about it is contained in a spatial weights matrix W. However, in practice, the structure of W is unknown a priori and difficult to obtain, especially for asymmetric dependence. In this paper, we propose a data-driven method to obtain W, whether it is symmetric or asymmetric. This is achieved by calculating the area overlap of the adjacent regions/districts with a given shape (a pizza-like shape, in our case). With W determined in this way, we estimate the potentially asymmetric spatial autoregressive dependence on irregular lattices. We verify our method using Monte Carlo simulations for finite samples and compare it with classical approaches such as Queen’s contiguity matrices and inverse-distance weighting matrices. Finally, our method is applied to model the evolution of sales prices for building land in Brandenburg, Germany. We show that the price evolution and its spatial dependence are mainly driven by the orientation towards Berlin