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Longitudinal associations of DNA methylation and sleep in children : a meta-analysis
Authors
Isabella Annesi-Maesano
Anne Claire Binter
+37 more
Alba Cabré-Riera
Charlotte A.M. Cecil
Dana Dabelea
Janine F. Felix
Regina Grazuleviciene
Veit Grote
Kathrin Guerlich
Mònica Guxens
Kristine L. Haftorn
Jonathan A. Heiss
Gunda Herberth
Barbara Heude
Marie France Hivert
Siri E. Håberg
M. Elisabeth Koopman-Verhoeff
Tuomas Kvist
Jari Lahti
Stephanie J. London
Annemarie I. Luik
Anni L.K. Malmberg
Rosa H. Mulder
Christian M. Page
Giancarlo Pesce
Sabine Plancoulaine
Katri Raikkonen
Caroline L. Relton
Rebecca C. Richmond
Sheryl L. Rifas-Shiman
Stefan W. Röder
Sara Sammallahti
Gemma C. Sharp
Anne P. Starling
Henning Tiemeier
Marina Vafeiadi
Melanie Waldenberger
Rory Wilson
Ana C. Zenclussen
Publication date
1 January 2022
Publisher
Doi
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on
PubMed
Abstract
Publisher Copyright: © 2022, The Author(s).Background: Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods: We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results: We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × 10–8). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × 10–8, n = 577) and sleep onset latency (p = 8.8 × 10–9, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion: DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available.Peer reviewe
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