Hellinen, Laura

Hongisto, Heidi

Kaarniranta, Kai

Ramsay, Eva

Ruponen, Marika

Skottman, Heli

Vellonen, Kati-Sisko

English

Helsingin yliopiston digitaalinen arkisto

https://helda.helsinki.fiRetraction: Hellinen et al. Drug Flux across RPE Cell Models:þÿ T h e   H u n t   f o r   a n   A p p r o p r i a t e   O u t e r   B l o o d  R e t i n a l   B a r r i e r   M o d e lfor Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176Hellinen, LauraMultidisciplinary Digital Publishing Institute2022-03-09Hellinen, L.; Hongisto, H.; Ramsay, E.; Kaarniranta, K.; Vellonen, K.-S.; Skottman, H.;Ruponen, M. Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for anþÿ A p p r o p r i a t e   O u t e r   B l o o d  R e t i n a l   B a r r i e r   M o d e l   f o r   U s e   i n   E a r l y   D r u g   D i s c o v e r y .Pharmaceutics 2020, 12, 176. Pharmaceutics 2022, 14, 595.http://hdl.handle.net/10138/349253Downloaded from Helda, University of Helsinki institutional repository.This is an electronic reprint of the original article.This reprint may differ from the original in pagination and typographic detail.Please cite the original version.Citation: Hellinen, L.; Hongisto, H.;Ramsay, E.; Kaarniranta, K.; Vellonen,K.-S.; Skottman, H.; Ruponen, M.Retraction: Hellinen et al. Drug Fluxacross RPE Cell Models: The Hunt foran Appropriate Outer Blood–RetinalBarrier Model for Use in Early DrugDiscovery. Pharmaceutics2020,12, 176.Pharmaceutics2022, 14, 595. https://doi.org/10.3390/pharmaceutics14030595Received: 28 February 2022Accepted: 8 March 2022Published: 9 March 2022Publisher's Note: MDPI stays neutralwith regard to jurisdictional claims inpublished maps and institutional afl-iations.Copyright: © 2022 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).RetractionRetraction: Hellinen et al. Drug Flux across RPE Cell Models:The Hunt for an Appropriate Outer Blood–Retinal BarrierModel for Use in Early Drug Discovery. Pharmaceutics2020,12, 176Laura Hellinen 1 , Heidi Hongisto 2 , Eva Ramsay3 , Kai Kaarniranta 2,4 , Kati-Sisko Vellonen 1,Heli Skottman 5 and Marika Ruponen 1,*1 School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70210 Kuopio, Finland;laura.pelkonen@uef. (L.H.); kati-sisko.vellonen@uef. (K.-S.V.)2 Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland,70210 Kuopio, Finland; heidi.m.hongisto@tuni. (H.H.); kai.kaarniranta@uef. (K.K.)3 Drug Research Programme, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University ofHelsinki, P.O. Box 56, FI-00014 Helsinki, Finland; eva.ramsay@helsinki.4 Department of Ophthalmology, Kuopio University Hospital, P.O.Box 100, FI-70029 Kuopio, Finland5 Faculty of Medicine and Health Technology, BioMediTech, Tampere University, 33520 Tampere, Finland;heli.skottman@tuni.* Correspondence: marika.ruponen@uef.The published article [ 1] has been retracted due to data errors. During a review of thedata, the authors found that the studied LEPI-1 cell line is not derived from the ARPE-19RPE cell line of the human origin as described in the article but rather originates fromthe Madin-Darby canine (Canis familiaris) kidney cell line with the human MDR1 gene(MDCK-MDR1). This incorrect interpretation of the cell origin was a consequence of cellline cross-contamination and an error in characterization process.The outcome and conclusions of the study were affected, so it was decided that acorrection would not be appropriate, and the paper will therefore be retracted. We apologizefor any inconvenience caused by the removal of this article.To ensure the addition of only high quality scientic works to the eld of scholarlypublication, this article [ 1] is retracted and shall be marked accordingly. We apologize tothe readers of Pharmaceutics.Reference1. Hellinen, L.; Hongisto, H.; Ramsay, E.; Kaarniranta, K.; Vellonen, K.-S.; Skottman, H.;Ruponen, M. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics2020, 12, 176. [CrossRef][PubMed]Pharmaceutics2022, 14, 595. https://doi.org/10.3390/pharmaceutics14030595 https://www.mdpi.com/journal/pharmaceutics

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

https://helda.helsinki.fi/bitstream/10138/349253/1/pharmaceutics-14-00595.pdf

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

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