MAPPING THE BOVINE CYSTIC FIBROSIS GENE

Abstract

Program year: 1992/1993Digitized from print original stored in HDRHuman cDNA probe H1. 6 (clone 10-1) encoding cystic fibrosis transmembrane conductance regulator (CFTR) was used to map the bovine homolog of CFTR. Using a panel of bovine X rodent hybrid somatic cells, the homolog was mapped to bovine syntenic group U13. CFTR is 97.7% concordant with syntenic markers T-cell receptor beta (TCRB) and P-glycoprotein 3 (PGY3) previously mapped on U13. The comparative gene maps of CFTR, TCRB, and PGY3 on human chromosome 7, bovine syntenic group U13, and mouse chromosomes 5 and 6 indicate considerable evolutionary conservation