The study examined the relationship that exists between academic resilience and information literacy self-efficacy among final year pre-service school librarians in a selected University in Nigeria. This study adopted the correlational survey research design. Through multistage sampling technique, 60 final year students of Library and Information science were selected. The questionnaires such as Academic Resilience Scale (ARS) and Information Literacy Self-Efficacy Scale (ILSES) were used to collect data. Linear regression was used to test the null hypotheses. The correlation coefficient of R=0.601 shows that there was a moderate positive association between academic resilience and information literacy self-efficacy. The regression of ANOVA of F(1,58) = 32.863, p = 0.00 indicated that there was a significant moderate relationship between academic resilience and information literacy self-efficacy of final year pre-service school librarians. The findings further indicated that final year pre-service librarians’ academic resilience is a significant predictor of their information literacy self-efficacy irrespective of gender and age