CIS群はcontrol群の約2倍の核容積を示し, 正常粘膜と明らかに区別できた.本法は非腫瘍部分の変化を客観的に表す方法としても有用である.組織学的に正常と診断された粘膜にも核容積が増大した部分がみられたThe mean nuclear volume (MNV) of non-tumorous bladder mucosa in 27 patients with a bladder tumor was estimated by using a new stereological method, "vertical section". Eighty four specimens were obtained by punch biopsy from preselected sites of urinary bladder. Thirteen specimens (10 patients) out of 84 were histologically diagnosed as carcinoma in situ (CIS). Bladder mucosa of 24 patients with various benign diseases were also measured as normal controls. The MNV of the normal control group was 127.1 +/- 19.6 microns 3 (mean +/- standard error) and that of the specimens diagnosed with CIS was 279.6 +/- 69.0 microns 3. There was no overlap between the two groups. Out of 71 specimens diagnosed as having no malignancy, 30 (42.3%) exhibited significantly increased MNV. Estimation of the MNV of non-tumorous bladder mucosa may be useful for standardization of CIS. Further studies are needed to investigate the role of the increased MNV in histologically normal mucosa in the course of a bladder tumor
