Introduction: The PTEN gene acts as a tumor suppressor gene and there are
various mechanisms involved to suppress its function, including mutation,
homozygous deletion, and promoter methylation. Recently, the role of PTEN
loss is focused on drug resistance mechanism, such as gefitinib. We investigated
PTEN protein expression in non-small cell lung cancer (NSCLC) and
correlated with clinicopathologic features to evaluate prognostic significance.