This document sets out the theoretical and practical fundamentals to guide users in the imple- mentation of Raman spectroscopy in industry or the university-hospital sector. It describes the principle of this technique and currently available instruments. Since Raman spectrometers are used in a regulated context, the methodology of instru- ment qualification is discussed. Different types of applications encountered in the pharmaceutical field are presented: process monitoring, searching for and detecting counterfeits, and identifying raw materials on receipt