Kerry, Sheila

Lambon Ralph, Matt

Leff, Alex P.

Rice, Grace

Robotham, Ro Julia

Starrfelt, Randi

English

Copenhagen University Research Information System

u n i ve r s i t y  o f  co pe n h ag e n  Københavns UniversitetSay hello to BoBRobotham, Ro Julia; Kerry, Sheila; Rice, Grace; Leff, Alex P.; Lambon Ralph, Matt; Starrfelt,RandiPublication date:2017Document versionPublisher's PDF, also known as Version of recordCitation for published version (APA):Robotham, R. J., Kerry, S., Rice, G., Leff, A. P., Lambon Ralph, M., & Starrfelt, R. (2017). Say hello to BoB:Introducing the Back of the Brain Project. Poster session presented at 6th Scientific meeting of the Federation ofthe European Societies of Neuropsychology, Maastricht, Netherlands.Download date: 03. Feb. 2020:    Julia Robotham1, Sheila Kerry2, Grace Rice3, Alex Leff2, Matt Lambon-Ralph3 & Randi Starrfelt1 1Department of Psychology, University of Copenhagen 2Institute of Cognitive Neuroscience, University College London 3The Neuroscience and Aphasia Research Unit (NARU), University of Manchester  Say hello to BoB Introducing the Back of the Brain Project Left hemisphere Right hemisphere Background Face and words recognition has traditionally been thought to rely on highly specialised and relatively independent cognitive processes.  Strong evidence for this has come from single case studies of patients with: • pure prosopagnosia: a selective face recognition deficit • pure alexia: a selective word recognition deficit  Recent theories, such as the many-to-many hypothesis (Behrmann & Plaut, 2013), suggest instead that the cognitive and cerebral processes underlying visual recognition are more distributed and interactive. While single case studies are well suited to investigate dissociations between deficits, larger groups of patients are needed to investigate associations predicted by a distributed model.     International collaboration Study design University of Copenhagen • Prof. Randi  Starrfelt • Ph.d. student: Julia Ro Robotham Patient/control  recruitment  and assessment University College London • Prof. Alex Leff • Postdoc: Sheila Kerry University of Manchester • Prof. Matt Lambon-Ralph • Postdoc: Grace Rice What’s novel? • Participants selected according to lesion localization, not according to symptoms à Expecting novel patterns of lesions and symptoms. • All participants assessed with the same wide range of functions with sensitive tests à Enabling direct comparison across subjects, which is often not possible across single case studies. • Tests of face, word and object processing: Same level of processing tested across stimulus type.  • Large group of PCA patients included.  Status • 25 patients tested (right lesions n = 6; left lesions n = 16; bilateral lesions n = 3) • 3 control participants tested  Handwriting recognition test Topographical disorientation: The wayfinding questionnaire Semantic processes and language Word processing - Neale: text reading - Reading 3,5,7 letter words (RT) - Reading regular, irregular and non-words (RT) - Letter, digit, and word naming: RT - Single item report:: letters, digits and words (short presentation) - Lexical decision - Surprise recognition task: words - Delayed matching task: words Object processing - Picture naming - Object categorization - Object decision test: yes/no - Cambridge house memory test - Surprise recognition task: objects - Delayed matching task: objects Face processing - Famous face naming - Famous face familiarity test: yes/no - Cambridge face memory test - Surprise recognition task: faces - Delayed matching task: faces - Writing to dictation - Semantics: Synonym judgement task Intermediate and low-level visual perception Background information IDENTIFICATION RECOGNITION - Intermediate visual perception: L-post - Visual field test: Copenhagen perimetry - Visual acuity: FrACT (Landolt C) - Colour perception: D-15 test - Contrast sensitivity: the functional acuity contrast test - Handedness: Edinburgh short-form (5 items) - Depression:  Geriatric depression  scale: GDS-15 - Cognition: Oxford Cognitive Screen; Digit span (WASI): forwards and backwards - Basic motor response time: Simple visual RT test (up vs down) - Premorbid reading: Adult reading history questionnaire - Premorbid face recognition: Faces and emotions questionnaire Figure 1:  Behavioural test battery Methods      70-100 patients  (stroke in  posterior cerebral artery) 50 healthy controls (matched as group for age and education) Behavioural tests All patients are assessed (>9 months post-stroke) a large battery of sensitive behavioural tests (see figure 1 for overview of functions assessed). Assessment of each patient carried out over 3 days (within maximum 3 weeks). Imaging • Structural T1 scan • Functional localiser: faces and scrambled faces, words and checkerboards • Diffusion tensor imaging (DTI) scan  Aim of the study The study aims to shed new light on the processes and cerebral architecture underlying visual recognition of faces and words. Some of the core research questions:  • Do face and word processing rely on processes that are largely independent or highly distributed and shared? • What is the relationship between deficits in object, word or face processing and lower-level and intermediate visual perceptual deficits? • Is there a relationship between premorbid reading skills and type and severity of alexia and prosopagnosia following stroke?  • How do visual field defects affect higher-level visual perception? • How are visual recognition and semantics related? • Can reading be spared after a lesion in the left fusiform gyrus  and can face recognition be spared after a lesion in the right fusiform gyrus?  View publication stats

Say hello to BoB:Introducing the Back of the Brain Project

https://curis.ku.dk/ws/files/194973874/Robotham_BoB_FESN2017Poster.pdf

Say hello to BoB:Introducing the Back of the Brain Project

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