It was previously demonstrated that secretin influenced the behavior of rats
investigated by open-field test. In the present experiment, we have compared the
effect of intracerebroventricular administration of 2 mug of secretin on the
behavior of CFLP white and Japanese waltzing mice. These latter animals exhibit
stereotypic circular movements. The effect of secretin on the horizontal
(ambulation) and vertical movements (rearing and jumping) was investigated in
open-field test. The ambulation time and distance were shorter, and the number of
rearing and jumping were much lower in Japanese waltzing mice than in CFLP white
mice during 30 min-experimental period. In white mice, 2 mug of secretin had no
effect on the above-mentioned parameters; however, in Japanese waltzing mice,
secretin enhanced the ambulation time and distance to the level of CFLP white
mice, but did not influence the rearing and jumping. On the basis of the results,
it was concluded that intracerebroventricularly administered secretin attenuated
the stereotypic (circulating) movement and improved the horizontal movement
indicated by the normalization of the ambulation time and distance; however, it
did not influence the explorative behavior (rearing and jumping) in our special
animal model
