Missing data remains a prevalent issue in every area of research. The impact of missing data, if not carefully handled, can be detrimental to any statistical analysis. Some statistical challenges associated with missing data include, loss of information, reduced statistical power and non-generalizability of findings in a study. It is therefore crucial that researchers pay close and particular attention when dealing with missing data. This multi-paper dissertation provides insight into missing data across different fields of study and addresses some of the above mentioned challenges of missing data through simulation studies and application to real datasets. The first paper of this dissertation addresses the dropout phenomenon in single-cell RNA (scRNA) sequencing through a comparative analyses of some existing scRNA sequencing techniques. The second paper of this work focuses on using simulation studies to assess whether it is appropriate to address the issue of non-detects in data using a traditional substitution approach, imputation, or a non-imputation based approach. The final paper of this dissertation presents an efficient strategy to address the issue of imbalance in data at any degree (whether moderate or highly imbalanced) by combining random undersampling with different weighting strategies. We conclude generally, based on findings from this dissertation that, missingness is not always lack of information but interestingness that needs to investigated
