Harmonic sounds or harmonic components of sounds are often fused into a single percept by the auditory system. Although the exact neural mechanisms for harmonic sensitivity remain unclear, it arises presumably in the auditory cortex because subcortical neurons typically prefer only a single frequency. Pitch sensitive units and harmonic template units found in awake marmoset auditory cortex are sensitive to temporal and spectral periodicity, respectively. This thesis is a study of possible computational mechanisms underlying cortical harmonic selectivity.
To examine whether harmonic selectivity is related to statistical regularities of natural sounds, simulated auditory nerve responses to natural sounds were used in principal component analysis in comparison with independent component analysis, which yielded harmonic-sensitive model units with similar population distribution as real cortical neurons in terms of harmonic selectivity metrics. This result suggests that the variability of cortical harmonic selectivity may provide an efficient population representation of natural sounds.
Several network models of spectral selectivity mechanisms are investigated. As a side study, adding synaptic depletion to an integrate-and-fire model could explain the observed modulation-sensitive units, which are related to pitch-sensitive units but cannot account for precise temporal regularity. When a feed-forward network is trained to detect harmonics, the result is always a sieve, which is excited by integer multiples of the fundamental frequency and inhibited by half-integer multiples. The sieve persists over a wide variety of conditions including changing evaluation criteria, incorporating Dale’s principle, and adding a hidden layer. A recurrent network trained by Hebbian learning produces harmonic-selective by a novel dynamical mechanism that could be explained by a Lyapunov function which favors inputs that match the learned frequency correlations. These model neurons have sieve-like weights like the harmonic template units when probed by random harmonic stimuli, despite there being no sieve pattern anywhere in the network’s weights.
Online stimulus design has the potential to facilitate future experiments on nonlinear sensory neurons. We accelerated the sound-from-texture algorithm to enable online adaptive experimental design to maximize the activities of sparsely responding cortical units. We calculated the optimal stimuli for harmonic-selective units and investigated model-based information-theoretic method for stimulus optimization
