Abdirahman, A.

Behning, C.

Binns, A. M.

Crabb, D. P.

Dunbar, H.

Higgins, B. E.

Luhmann, U. F. O.

Montesano, G.

Poor, S.

Rubin, G. S.

Schmid, M.

Taylor, D. J.

Terheyden, J. H.

Zakaria, N.

City Research Online

              City, University of London Institutional RepositoryCitation: Dunbar, H., Behning, C., Taylor, D. J., Higgins, B. E., Montesano, G., Binns, A. M., Terheyden, J. H., Abdirahman, A., Zakaria, N., Poor, S., et al (2021). MACUSTAR cross-sectional data: Repeatability and discriminatory power of visual function tests. Investigative Ophthalmology & Visual Science, 62(8), ISSN 0146-0404 This is the published version of the paper. This version of the publication may differ from the final published version. Permanent repository link:  https://openaccess.city.ac.uk/id/eprint/28904/Link to published version: Copyright: City Research Online aims to make research outputs of City, University of London available to a wider audience. Copyright and Moral Rights remain with the author(s) and/or copyright holders. URLs from City Research Online may be freely distributed and linked to.Reuse: Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. City Research OnlineCity Research Online:            http://openaccess.city.ac.uk/            publications@city.ac.uk1/2MACUSTAR cross-sectional data: Repeatability anddiscriminatory power of visual function tests | IOVSiovs.arvojournals.org/article.aspxJune 2021Volume 62, Issue 8ARVO Annual Meeting Abstract  |   June 2021MACUSTAR cross-sectional data: Repeatability and discriminatory power of visualfunction testsHannah M P Dunbar; Charlotte Behning; Deanna J Taylor; Bethany Elora Higgins;Giovanni Montesano; Alison Binns; Jan Henrik Terheyden; Amina Abdirahman; NadiaZakaria; Stephen Poor; Gary S Rubin; Matthias Schmid; David P. Crabb; Ulrich F OLuhmannAuthor Affiliations & NotesInvestigative Ophthalmology & Visual Science June 2021, Vol.62, 302. doi:MACUSTAR cross-sectional data: Repeatability and discriminatory power ofvisual function tests×Hannah M P Dunbar, Charlotte Behning, Deanna J Taylor, Bethany EloraHiggins, Giovanni Montesano, Alison Binns, Jan Henrik Terheyden, AminaAbdirahman, Nadia Zakaria, Stephen Poor, Gary S Rubin, Matthias Schmid,David P. Crabb, Ulrich F O Luhmann; MACUSTAR cross-sectional data:Repeatability and discriminatory power of visual function tests. Invest.Ophthalmol. Vis. Sci. 2021;62(8):302.© ARVO (1962-2015); The Authors (2016-present)×AbstractPurpose : To examine the repeatability of a visual function (VF) test battery and its powerto discriminate between structurally defined age-related macular degeneration (AMD)stages.Methods : Subjects with no AMD and Beckman defined early(e), intermediate(i) andlate(l) AMD were recruited across 18 European study sites. All subjects performed a VFbattery at day 0 and 14 ± 7 comprising chart-based [Best-Corrected Visual Acuity (BCVA),Low Luminance Visual Acuity (LLVA), Moorfields Acuity Test (MAT), Pelli Robson ContrastSensitivity (CS) and International Reading Speed Test (IReST); and novel tests [Mesopic2/2(MesAT) and Scotopic (ScoAT) average thresholds by S-MAIA microperimetry andAdaptDx Rod Intercept Time (RIT)]. Repeatability of all measures was assessed byIntraclass Correlation Coefficients (ICC). Discriminant ability to distinguish between thosewith and without AMD and between neighbouring disease severity states was evaluatedusing Receiver Operator Characteristic (ROC) analyses, reporting Area Under the Curve(AUC) and partial (pAUC) at 80% specificity. Here we report the ability to distinguishbetween no AMD and iAMD.Results : 301 subjects were recruited. 290 completed both visits [eAMD (n=28), iAMD (n= 167), lAMD (n=41) and no AMD (n=54)]. The cohort was roughly 2/3  female (62.1%)with a mean age of 71. Repeatability was higher for chart-based than novel tests, withchart-based ICCs ranging from 0.88 (CS) to 0.96 (BCVA), whereas novel test ICCsranged between 0.27 (RIT) and 0.93 (ScoAT) when all cases were considered and 0.73(RIT) and 0.93 (ScoAT) when 3 extrapolated RIT values were removed. Discriminatorypower of chart-based tests between no AMD and iAMD was moderate with AUCs ofbetween 0.57 (IReST, pAUC = 0.04) and 0.77 (CS, pAUC = 0.08). Considering noveltests, discriminatory ability of microperimetry between no AMD and iAMD was moderate,and higher for scotopic testing (MesAT: AUC = 0.67; pAUC = 0.05; ScoAT: AUC = 0.70;pAUC = 0.06), whereas RIT values were slightly better, particularly when pAUCs wereconsidered (RIT: AUC = 0.71; pAUC = 0.09).Conclusions : Though CS, MesAT, ScoAT and RIT demonstrate moderate discriminatorypower between no AMD and iAMD, a sizable proportion of iAMD subjects had normal VF.Given the substantial phenotypic variation in structurally defined iAMD, subgroupanalyses are required to identify those with poorest VF and potential structural correlates.This is a 2021 ARVO Annual Meeting abstract.This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.Copyright © 2015 Association for Research in Vision and Ophthalmology.Copyright © 2015 Association for Research in Vision and Ophthalmology.rd

MACUSTAR cross-sectional data: Repeatability and discriminatory power of visual function tests

https://openaccess.city.ac.uk/id/eprint/28904/1/iovs.arvojournals.org-MACUSTAR%20cross-sectional%20data%20Repeatability%20and%20discriminatory%20power%20of%20visual%20function%20tests%20%20IOVS.pdf

MACUSTAR cross-sectional data: Repeatability and discriminatory power of visual function tests

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