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Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Authors
Dimitri Eigel
Mark Gumbleton
+9 more
Chloé Hoornaert
Debbie Le Blon
Catia Neto
Ben Newland
Peter Ponsaerts
Anne E. Rosser
Lucas Schirmer
Petra B. Welzel
Carsten Werner
Publication date
1 January 2020
Publisher
Cambridge : Royal Soc. of Chemistry
Doi
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Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. © 2020 The Royal Society of Chemistry
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oai:oa.tib.eu:123456789/6793
Last time updated on 23/07/2022