Ecder, Tevfik

Ergün, İhsan

Keven, Kenan

Nergizoğlu, Gökhan

Sadioğlu, Rezzan Eren

Üstüner, Evren

Nephrology Dialysis Transplantation

English

Ufuk Universitesi Akademik Acikerisim Sistemi

P1293 WARFARIN INCREASES THE RISK OF VASCULARCALCIFICATION IN HAEMODIALYSIS PATIENTS: AMULTICENTER CASE-CONTROL STUDYRezzan Eren Sadioglu1, Evren €Ustüner2, _Ihsan Ergün3, Tevfik Ecder4,Gökhan Nergizoglu1, Kenan Keven11Ankara University School of Medicine, Ibni Sina Hospital, Department of Nephrology,Ankara, Turkey, 2Ankara University School of Medicine, Ibni Sina Hospital, Departmentof Radiology, Ankara, Turkey, 3Ufuk University School of Medicine, Department ofNephrology, Ankara, Turkey and 4Demiroglu Bilim University School of Medicine,Department of Nephrology, _Istanbul, TurkeyBackground and Aims: Vascular calcifications (VC) are highly prevalent in mainte-nance haemodialysis patients and it is a recognized risk factor for increased mortality.Previous experimental studies showed the relation between warfarin which has beenprescribed frequently in dialysis patients and VC. The aim of this study is to investigatethe association between VC and warfarin use in haemodialysis patients.Method: This was a cross-sectional, observational, multicenter study. VC were assessedusing Adragao (AS; pelvis and hands) and Kauppila (KS; lateral lumbar spine) scores in76 haemodialysis patients from six centers. There were 32 patients (4.5%) being treatedwith warfarin for at least 1 year out of a total 711 haemodialysis patients and weincluded 44 control patients with matching parameters of age, sex and dialysis vintageto the study. Clinical characteristics, concomitant treatments, laboratory results wererecorded and possible risk factors related to VC were analyzed.Results: Of the patients, 47% were females, mean age was 65.8 6 9 years, 23% were dia-betics, their mean dialysis vintage was 68.39 6 38.5 months and mean Kt/V 1.66 60.27. No significant differences in clinical characteristics and basic laboratory resultswere found between control and warfarin group. In warfarin group, median Kauppilascore was higher than control [11 vs 6.5, (25%-75% percentile, 5 vs 15), P=0.032] andpercentages of Kauppila score>6 patients were higher, as well (76,6% vs 50%;P=0.029). Median Adragao score was not significantly different between two groups [7vs 6, (%25,%75 percentile 6 vs 8), P=0.177]. Logistic regression analysis revealed thatwarfarin treatment was independently associated with Kauppilla scores of>6 (OR3.28, 95% CI 1.17-9.22, P=0.024).Conclusion: The results of this study showed that warfarin is a strong risk factor forvascular calcifications, especially in aorta of haemodialysis patients.Table 1. Basic characteristics of the patients and summary of the resultsParameter Warfarin(+) n=32Warfarin(-) n=44P valueAge (mean6SD) 67.669 64.5468.3 0.143Female/Male 14; 43%/18; 56% 22; 50%/ 22; 50% 0.646Dialysis vintage (months,mean6SD)74.9644.2 63.6633.4 0.209Kt/V 1.6260.2 1.760.2 0.205Diabetes mellitus +/-(n,%)6, 18% 12, %27 0,427Warfarin usage time(months, mean6SD)65.969.7 NA NAKauppilla score (median,-min-max)11 (1-24) 6,5 (1,20) 0,032Kauppilla score >6 (n, %) 23, 76.6% 22, 50% 0,029Adragao score (median,min-max)7 (2-8) 6 (0-8) 0,177Adragao score  3 (n, %) 30, 93.7% 41, 93.1% 0,638Serum calcium(mean6SD)8.8260.5 8.7860.5 0.778Serum phosphorus(mean6SD)4.6260.87 4.8460.89 0.279Serum parathyroid hor-mone (mean6SD)376.236192.8 457.366251.2 0.116Serum albumin(mean6SD)3.8160.38 3.9160.52 0.361Serum hemoglobin(mean6SD)11.4361.1 11.661.57 0.595Serum C-reactive protein(mean6SD)14.3612.2 13.8615.4 0.881Figure:Abstracts Nephrology Dialysis Transplantationiii1616 | AbstractsDownloaded from https://academic.oup.com/ndt/article/35/Supplement_3/gfaa142.P1293/5853986 by guest on 28 September 2021

Warfarın increases the risk of vascular calcification in haemodialysis patients a multicenter case-control study

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Warfarın increases the risk of vascular calcification in haemodialysis patients a multicenter case-control study

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