International Journal of Sciences: Basic and Applied Research
Abstract
Introduction: The histological grade of the tumor influences the prognosis of breast cancer. In metastatic breast cancer, the stromal cells produce a chemokine (C-X-C motif chemokine 12/CXCL12) or the so-called stromal-derived factor-1 (SDF-1) as a chemoattractant, which binds to the chemokine receptor (C-X-C chemokine receptor type 4/CXCR4) which is expressed by breast cancer cells. This study aimed to determine the expression of CXCR4 in invasive breast cancer associated with histopathological grading of invasive breast cancer.
Methods: This study is observational with a retrospective approach using a paraffin block archive sample diagnosed with Invasive Breast Cancer. Immunohistochemical staining using CXCR4 antibody and expression analysis was performed by light microscopy. The data were statistically analyzed by the Chi-Square test and presented in the table. The statistical test results were significant if the p-value was <0.05.
Results: Showed no significant relationship between CXCR4 expression and histopathological grading in invasive breast cancer with a p-value = 0.467.
Conclusion: The data of this study showed that the expression of CXCR4 in Invasive Breast Cancer varied and did not support its role in determining histopathological grading
