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Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice
Authors
Tapan Bhavsar
Genevieve M. Crane
Publication date
1 August 2020
Publisher
Health Sciences Research Commons
Abstract
© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: Our understanding of risk factors and mechanisms underlying immunosuppression-related lymphoproliferative disorders continues to evolve. An increasing number of patients are living with altered immune status due to HIV, solid organ or hematopoietic stem cell transplant, treatment of autoimmune disease, or advanced age. This review covers advances in understanding, emerging trends, and revisions to diagnostic guidelines. Recent Findings: The tumor microenvironment, including interactions between the host immune system and tumor cells, is of increasing interest in the setting of immunosuppression. While some forms of lymphoproliferative disease are associated with unique risk factors, common mechanisms are also emerging. Indolent forms, such as Epstein-Barr virus positive mucocutaneous ulcer, are important to recognize. As methods to modulate the immune system evolve, more data are needed to understand and minimize lymphoproliferative disease risk. Summary: A better understanding of individual risk factors and common mechanisms underlying immunosuppression-related lymphoproliferations will ultimately enable improved prevention and treatment of these disorders
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George Washington University: Health Sciences Research Commons (HSRC)
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Last time updated on 03/12/2020