Using a qualitative approach, this research project examined the practices of charism formation and mission education at institutions of higher education founded by Dominican Sisters in the US. Broad surveys of those in roles responsible for mission at the institutions were followed by select site visits—conducted in person and virtually—and interviews. Websites and published materials about the institutions, curriculum, visible signs on campus and activities that are integral to the mission were examined as part of this project. As the number of Dominican Sisters available to serve in their founded institutions decreases, this research may provide a path forward in ways by which institutions can continue their original inspiration in ever-changing times. Themes of collaboration, integration, and prioritizing minority populations are common among the ways that Dominican institutions continue working in the spirit of their founders