Lancaster-Shorts, Katrina

Pirruccello, Samuel

English

University of Nebraska Medical Center Research: DigitalCommons@UNMC

Graduate Medical Education Research Journal Volume 2 Issue 1 Article 65 September 2020 CD24 Expression in Follicular Lymphoma: An Alternative B-Cell Marker in Therapy Selected, Recurrent Lymphoma Katrina Lancaster-Shorts et al. Follow this and additional works at: https://digitalcommons.unmc.edu/gmerj  Part of the Higher Education Commons, and the Medicine and Health Sciences Commons Recommended Citation Lancaster-Shorts, K. CD24 Expression in Follicular Lymphoma: An Alternative B-Cell Marker in Therapy Selected, Recurrent Lymphoma. Graduate Medical Education Research Journal. 2020 Sep 29; 2(1). https://digitalcommons.unmc.edu/gmerj/vol2/iss1/65 This Conference Proceeding is brought to you for free and open access by DigitalCommons@UNMC. It has been accepted for inclusion in Graduate Medical Education Research Journal by an authorized editor of DigitalCommons@UNMC. For more information, please contact digitalcommons@unmc.edu. CD24 Expression in Follicular Lymphoma: An Alternative B-Cell Marker in Therapy Selected, Recurrent Lymphoma Creative Commons License This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License. This conference proceeding is available in Graduate Medical Education Research Journal: https://digitalcommons.unmc.edu/gmerj/vol2/iss1/65 Graduate Medical Education Research Journal56 Poster Presentations*Names in bold type indicate presenting author.quantity of MME prescribed at discharge 	postoperative visit (r = 0.25, p = 0.02) but not the second postoperative visit (r = 0.17, p = association between MME prescribed and fracture characteristics or patient variables.Conclusion: Postoperative opioid use correlated only with subjective, patient 	but did not correlate with injury mechanism, fracture characteristics, or patient variables. https://doi.org/10.32873/unmc.dc.gmerj.2.1.063References 1 Sairam Atluri, M.G.S., MD; Laxmaiah Manchikanti, MD, Assessment of the Trends of Medical Use and Misuse of Opioid Analgesics from 2004 to 2011. Pain Physician, 2014. 17: p. E119-E128.2 Laxmaiah Manchikanti, M.A.S., BS, BA, Therapeutic Opioids: A Ten-Year Perspective on the Complexities and Complications the Escalating Use, Abuse, and Nonmedical Use of Opioids. Pain Physician, 2008. 11: p. S63-S88.3 Boylan, M.R., et al., Patterns of Narcotic Prescribing by Orthopedic Surgeons for Medicare Patients. Am J Med Qual, 2018: p. 1062860618771190.4 Attum, B., et al., Opioid Prescribing Practices by Orthopaedic Trauma Surgeons After Isolated Femur Fractures. J Orthop Trauma, 2018. 32(3): p. e106-e111.5 Yu, N.N., et al., Persistence of Opioid Prescribing after a Forearm or Lower Leg Fracture. J Gen Intern Med, 2018. 33(3): p. 251-252.6 Teng, Z., et al., Opioids contribute to fracture risk: a meta-analysis of 8 cohort studies. PLoS One, 2015. 10(6): p. e0128232.7 Ping, F., et al., Opioids increase hip fracture risk: a meta-analysis. J Bone Miner Metab, 2017. 35(3): p. 289-297.8 Buchheit, T., et al., Opioid exposure is associated with nonunion risk in a traumatically injured population: An inception cohort study. , 2018.9 Seth, P., et al., Quantifying the Epidemic of Prescription Opioid Overdose Deaths. Am J Public Health, 2018. 108(4): p. 500-502.10 Bot, A.G., et al., Opioid use after fracture surgery correlates with pain intensity and satisfaction with pain relief.	, 2014. 472(8): p. 2542-9.11 Christensen, K.P., et al., The Effects of Anesthetic Technique on Postoperative Opioid Consumption in Ankle Fracture Surgery. Clin J Pain, 2016. 32(10): p. 870-4.12 Finger, A., et al., Association Between Opioid Intake and Disability After Surgical Management of Ankle Fractures. J Am Acad Orthop Surg, 2017. 25(7): p. 519-526.13 Helmerhorst, G.T.T., et al., Pain Relief After Operative Treatment of an Extremity Fracture: A Noninferiority Randomized Controlled Trial. J Bone Joint Surg Am, 2017. 99(22): p. 1908-1915.14 McDonald, E., et al., Effect of Postoperative Ketorolac Administration on Bone Healing in Ankle Fracture Surgery. Foot Ankle Int, 2018: p. 1071100718782489.15 Syed, U.A.M., et al., Neer Award 2018: the effect of preoperative education on opioid consumption in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial. J Shoulder Elbow Surg, 2018. 27(6): p. 962-967.CD24 Expression in Follicular Lymphoma: An Alternative B-Cell Marker in Therapy Selected,  Recurrent LymphomaKatrina Lancaster-Shorts1, Samuel Pirruccello11University of Nebraska Medical Center, Department of Pathology and MicrobiologyMentor: Samuel PirruccelloProgram: Pathology and MicrobiologyType: Original ResearchBackground: The rapidly expanding use of antigen targeted therapies, such as anti-CD19, anti-CD20 and anti-CD22, in B-cell malignancies will require the application of additional B-cell-associated antigens in the assessment of residual disease. CD24 is a !	surface density changes during normal maturation. In contrast to the loss of CD24 expression in normal follicles, we observed that follicle center derived lymphomas retain CD24 expression. Our aim was to determine the percentage of follicle center lymphomas with aberrant CD24 expression.Methods: We reviewed 334 patients with a diagnosis of follicular lymphoma (FL; 228), large cell lymphoma of follicular origin (59) or B-cell lymphoma of follicular origin "#$%&'*%++/!!+<>!	tissue diagnosis of FL or diffuse large B-cell lymphoma (DLBCL) were excluded leaving 113 patients with FL, 38 patients with CD10-positive DLBCL and 12 patients with mixed FL/DLBCL. We analyzed the percentage of patients with CD24 positive lymphomas in each of the three diagnostic categories.Results: We found that CD24 expression was retained in 89% of FLs (101/113), 63% (24/38) of DLBCLs and 42% (5/12) of mixed FL/DLBCL. Five cases of CD20 negative FL were CD24 positive.Conclusion: Our results show the utility of %>J+#V	''!%&https://doi.org/10.32873/unmc.dc.gmerj.2.1.065				 to Two Immunohistochemical AlgorithmsKatrina Lancaster-Shorts1, Ann Crowley1, Matthew Lunnin2, Allison Cushman-Vokoun1, Jane Yuan1, Catalina Amado1, Timothy Greiner1, Kai Fu1,  Hina Naushad Qureish11 University of Nebraska Medical Center, Department of Pathology and Microbiology  2 University of Nebraska Medical Center, Department of Internal Medicine, Division of Oncology and HematologyMentor: Naushad QureishiProgram: Pathology and MicrobiologyType: Original ResearchBackground: Diffuse large B-cell lymphoma (DLBCL) is divided into cell-of-origin (COO) groups: germinal center B-cell (GCB), non-GCB also known as activated B-cell (ABC) 		X!	!%!%[\/V"]^_`!"`{>algorithms, such as the Hans and Choi, were developed in lieu of mGEP on microarray, !	|'V	'%			"}}_^!Nanostring Lymph2Cx assay is capable of [\/V}}_^tissue.Methods: We studied 70 cases of DLBCL analyzed with the Lymph2Cx. Immunohistochemistry was performed on FFPE tissue sections using antibodies for CD10, BCL6, MUM1, GCET1 and FOXP1. Our aim was to determine the concordance 

CD24 Expression in Follicular Lymphoma: An Alternative B-Cell Marker in Therapy Selected, Recurrent Lymphoma

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CD24 Expression in Follicular Lymphoma: An Alternative B-Cell Marker in Therapy Selected, Recurrent Lymphoma

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