Parkinson’s disease (PD) is a second most neurodegenerative disorder caused by the progressive loss of mesencephalic dopaminergic neurons in the substantia nigra innervating the striatum. The existing conventional strategies that target PD are associated with numerous side effects and possess an economic burden. In recent years, there has been a growing interest in alternative therapies and the therapeutic use of natural products, especially those derived from plants. The aim of the present study is to evaluate the anti Parkinson activity of Ayurvedic formulation Saraswatham ghritham ( SG) in Rotenone induced Parkinson mice. For induction of parkinsons disese rotenone was injected i.p in mice at the dose of 3 mg/kg body weight, 7 days. After induction various doses of SG (100 mg/kg, 200 mg/kg and 400 mg/kg) were administrated ( p.0) for 21 days. To find out its Antiparkinsons activity various behavioral studies, biochemical estimations, neurotransmitter evaluations and histopathalological studies have been performed. The results were promising like the behavioral studies the rota rode the high dose SG treated group ( 400mg/kg ) the muscle grip strength(111.000±0.258 sec) was significantly increased compared to rotenone induced group (13.500±0.342). Treatment with SG results in regains the levels of endogenous antioxidant levels to normal values. Especially neuroprotective effect of SG was confirmed by histopathology. The inflammatory cells were absent , glial and astrocytes possess proper morphological features in SG treated group. So this study concludes the Antiparkinsons activity of saraswatha gritham
