Mortality is similar in both diphyllin and water control group. One of the triad which is metabolic acidosis does develop in diphyllin group. But it is seen in controls also. There is significant acidosis in diphyllin group in the initial hours. And the responses to acidosis like hyperventilation, hyperkalemia and acidic urine are similar in both the test and control groups. But because there is significant acidosis in the initial hours with diphyllin, Diphyllin may contribute a part to the development of severe metabolic acidosis which develops with whole aqueous extract.
Diphyllin produces metabolic acidosis, less severe than the whole aqueous extract. Diphyllin do not show hypokalemia or 100% alkaline urine as seen in the whole aqueous extract.
Mortality is only 16.66% as compared to 100% mortality in whole aqueous extract of Cleistanthus collinus.
Conclusive to say that diphyllin may not be the sole cause of distal renal tubular acidosis which is developing in poisoning with Cleistanthus collinus and DIPHYLLIN IS NON-TOXIC
