Previous research reports revealed that histamine H2 receptor blockers such as ranitidine and famotidine showed analgesic activity in rodent models. However, the analgesic or anti-nociceptive activity of nizatidine, a most widely used H2 receptor blocker, has not yet been reported. Hence, the present study was aimed to evaluate the probable anti-nociceptive and analgesic activities of nizatidine in valid animal models. The results obtained in this study revealed the anti-nociceptive and analgesic activities of nizatidine. However, further chronic studies are required to validate the analgesic and anti-nociceptive activities of nizatidine. In conclusion, nizatiine produces the anti-nociceptive and analgesic activities in valid animal models similar to that of other H2 receptor blockers
