The present study was aimed to evaluate the efficacy of Taurine and Trypyophan in Cuprizone model of multiple sclerosis. It was hypothised that Taurine and Tryptophan would be able to ameliorate the neuronal degeneration and neuroinflammation present in Multiple Sclerosis. The study was evaluated by assessment of various in vivo parameters like of learning and memory, locomotor activity and motor co ordination.The in vitro parameters like SOD, Catalase ,Glutathione reductase, Glutathione peroxidase and proinflammtoiry cytokine InterleuikZin-6 were also assessed. This study identified cuprizone as a neurotoxin capable of inducing oxidative stress. It also revealed the protective effect of Taurine and Tryptophan against CPZ-induced behavioral and neuropathological deficits in Swiss Albino mice
