Substituted oxadiazole, 5-(2-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione
was synthesized from salicylic acid.
The titled oxadiazole derivatives were synthesized by making substitution at
free N-(3H) position of 5-(2-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione
through mannich condensation.
Substituted oxadiazole, 5-(4-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione
was synthesized from p-hydroxy benzoic acid.
The titled oxadiazole derivatives were synthesized by making substitution at
free N-(3H) position of 5-(4-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione
through mannich condensation.
The synthesized compounds were characterized by melting point and
solubility and subjected to various analytical techniques like Thin Layer
Chromatography, IR and NMR spectral studies.
Synthesized compounds ODAZ 06, PDAZ 06, ODAZ 05, PDAZ 05, ODAZ
03, and PDAZ 03 compounds posses highly significant anti-convulsant
activity.
The synthesized compounds ODAZ 03, PDAZ 03, ODAZ 01, PDAZ 01
ODAZ 06, and PDAZ 06 possess significant anti-inflammatory activity at 90
mins.
The synthesized compound ODAZ 03 possesses highly significant antinociceptive
activity.
The synthesized compounds Compound, ODAZ 04, PDAZ 04, ODAZ 03,
PDAZ 03, ODAZ 02, PDAZ 02 posses significant anti-bacterial activity
against both G(+ve) and G(-ve) organisms.
The synthesized compounds Compound, ODAZ 03, PDAZ 03, ODAZ 04,
PDAZ 04, ODAZ 05, PDAZ 05 posses significant anti-fungal activity against
Candida albicans, Aspargillus nigar
The synthesized compounds Compound, ODAZ,ODAZ 05, PDAZ 05, ODAZ
04, PDAZ 04, ODAZ 03, PDAZ 03 posses significant anthelmintic activity
against pheritima posthum
