In mice models, the administration of a high fat diet (HFD) is an accelerating factor for metabolic syndrome, impaired glucose tolerance, and early type 2 diabetes mellitus (T2DM) (1)https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/1049/thumbnail.jp

Costa, Samantha

Pachón-­Peña, Gisela

Rosen, Clifford J

English

MaineHealth Knowledge Connection

MaineHealth MaineHealth Knowledge Connection Costas T. Lambrew Research Retreat 2021 Costas T. Lambrew Research Retreat 2021 The Effect of High Fat Diet on Marrow Adipocytes from C57BL/6J (B6) Mice Gisela Pachón-Peña Maine Medical Center Clifford J. Rosen Maine Medical Center Samantha Costa Maine Medical Center Follow this and additional works at: https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021  Part of the Dietetics and Clinical Nutrition Commons, and the Medical Cell Biology Commons Recommended Citation Pachón-Peña, Gisela; Rosen, Clifford J.; and Costa, Samantha, "The Effect of High Fat Diet on Marrow Adipocytes from C57BL/6J (B6) Mice" (2021). Costas T. Lambrew Research Retreat 2021. 40. https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/40 This Book is brought to you for free and open access by the Costas T. Lambrew Research Retreat at MaineHealth Knowledge Connection. It has been accepted for inclusion in Costas T. Lambrew Research Retreat 2021 by an authorized administrator of MaineHealth Knowledge Connection. α µαακαControl HFD010203040Dendritic Cells (MHCIIlow/CD11bhigh)Number of Cells (104)Control HFD02468T-Cells (CD8+)Number of Cells (104) nsControl HFD05101520Macrophages (Ly6C-/F4/80+)Number of Cells (104)Control HFD051015ST-HSC (CD48-/CD150-)Number of Cells (103)Control HFD0102030BV/TV (%)nsControl HFD4.04.55.05.5Tb.N (1/mm)nsControl HFD0.160.180.200.220.240.26Tb.Sp (mm)nsControl HFD0.0450.0500.0550.0600.0650.070Tb.Th (mm)nsControl HFD2030405060Weight (g)Control HFD1520253035Lean Mass (g)nsControl HFD0510152025Fat Mass (g)Control HFD01020304050Percent Fat (%)Control HFD020406080GTT AUC (x103 )αCT HFD0.00.20.40.60.81.0Gene Expression Relative to GAPDH (%)CT HFD0.000.050.100.150.20Gene Expression Relative to GAPDH (%)CT HFD0.000.020.040.060.080.10Gene Expression Relative to GAPDH (%)CT HFD0.00.51.01.52.02.5Gene Expression Relative to GAPDH (%)CT HFD0123Gene Expression Relative to GAPDH (%)0 15 30 45 60 1200200400600800Time Point (mins)Blood Glucose Level (mg/dL) Control HFD

The Effect of High Fat Diet on Marrow Adipocytes from C57BL/6J (B6) Mice

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The Effect of High Fat Diet on Marrow Adipocytes from C57BL/6J (B6) Mice

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