The aim of this work was to synthesize polymeric microparticles as carriers for nitrogen,
phosphorus, and potassium (NPK fertilizer) for agricultural applications, using polyglycerol (PG)
to improve the synthesis procedure. Multivariate experimental designs were employed to obtain a
satisfactory synthesis. The desirability function identified the best conditions for preparation of
the microparticles as being 100.00 mg of poly(e-caprolactone) (PCL), 825.00 mg of PG, 9.25 mL
of chloroform, and 0.9% w/v of polyvinyl alcohol (PVA). This resulted in average encapsulation
rates of 94.23% for N, 99.80% for P, and 65.00% for K. The profile of release from the microparticles
was according to diffusion following Fick?s Law. These observations confirmed the capacity
of the proposed microparticles to sustain a continuous and prolonged release of NPK for the purpose
of plant fertilization
