418-424Arthritis is an inflammatory joint disorder in which cartilage of the joint is gradually lost and categorized by swelling of
joints, pain, and loss of function. The present study was conducted to explore the antiarthritic activity of ethanolic extract of
Pithecellobium dulce against formaldehyde induced at sub plantar region of the left hind paw during days 1 and 3 of the
study period. The changes observed in paw diameter during the study period, various biochemical, and haematological
parameters were monitored. The Radiographic analysis and histopathology significantly improved after treatment with test
extract P. dulce (250 mg/kg, b.w., p.o.) as compared to the standard treatment with indomethacin (10 mg/kg, b.w., p.o.).The
results of the current investigation concluded that ethanolic extract of P. dulce possesses significant anti-arthritic activity
against formaldehyde induced arthritis model, justifying its therapeutic role in arthritic conditions. The observed antiarthritic
activity may be due to the presence of phytoconstituents such as alkaloids and flavonoids. P. dulce significantly suppressed
the paw oedema in formaldehyde models (P <0.001). The Histopathological and radiographic studies of joints also showed a
protective effect of P. dulce