The purpose of this study was to investigate the effects of a multi-ingredient pre-workout supplement (MIPS) on mental and physical performance. Seventeen exercise-trained men (n = 7) and women (n=10) completed this randomized, placebo-controlled, double-blind, counterbalanced, crossover trial. Participants consumed either a multi-ingredient pre-workout supplement (MIPS) or a placebo in a randomized, counterbalanced order. Forty-five minutes post-consumption, the following assessments were conducted: psychomotor vigilance test (PVT), Profile of Mood States (POMS), Stroop test, vertical jump test, and a Cold pressor test. There was a one-week washout period between assessments. There were significant differences in the incongruent task for the Stroop test where the treatment group had faster reaction times than the placebo group at the 45-minute post-consumption (reaction time: treatment 862 ± 160 ms, placebo 942 ± 204 ms, p = 0.0424). There were no significant differences between groups for the other indices of mood, the PVT, congruent scores of the Stroop test, vertical jump, or the Cold Pressor test. Thus, the acute consumption of a multi-ingredient pre-workout supplement produced a significant improvement in a sustained-attention, reaction-timed task
