Synthesis of fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers by 18 F‐for‐ 19 F exchange

Abstract

Fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers have been prepared by a facile 18 F‐for‐ 19 F isotopic exchange reaction. The isotopic exchange proceeds in good to excellent yields (up to 85%), and is dependent on reaction time, temperature, and concentration of reactants (aryl ether or fluoride ion). Substitution even occurs at room temperature in DMSO, and at elevated temperature (100 to 155°C) in DMSO or acetonitrile containing up to 20% water. Specific activities of 0.5‐55 Ci/mol have been achieved, with the products obtained in pure radiochemical and chemical form.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90133/1/2580281202_ftp.pd