Neuroprotective effects of pharmacologically induced hypothermia with delta-opioid receptor agonist DADLE and cannabinoid receptor agonist WIN55,212-2 during extracorporeal life support for cardiac arrest

Abstract

Extracorporeal life support (ECLS) and mild therapeutic hypothermia (TH) are regarded as effective therapeutic interventions for treating cardiogenic shock or cardiac arrest and post resuscitation care, respectively. However, the adverse neurological effects of therapeutic hypothermia have increasingly been recognized. Therefore, we investigated the neuroprotective effects of pharmacological induced hypothermia by delta-opioid receptor agonist d-Ala2-d-Leu5 enkephalin (DADLE) and cannabinoid receptor agonist WINN55,212-2 in comparison to conventional mild therapeutic hypothermia after resuscitation from cardiac arrest in an ECLS rat model