Gulya, K.

Harkany, T.

Jong, G.I. de

Luiten, P.G.M.

Penke, B.

Soós, K.

English

β-Amyloid(1-42) peptide (βAP(1-42)) was injected into the medial septum of rats. After a 14-day survival time, neuronal alterations in the septal cholinergic and GABAergic systems were visualized by means of histo- and immunocytochemical methods. Neurons insulted by the peptide were primarily choline acetyltransferase-immunoreactive (ir), while only minor effects of βAP(1-42) were observed on parvalbumin-ir interneurons. These results indicate that the changes in intracellular Ca2+ level elicited by βAP(1-42) may contribute to β-amyloid neurotoxicity, and Ca2+-binding proteins may play an important role in the protection against the neurotoxic effects of βAP(1-42)

Proceedings - University of Groningen

β-Amyloid(1-42) affects cholinergic but not parvalbumin-containing neurons in the septal complex of the rat

https://pure.rug.nl/ws/files/14505223/1995BrainResHarkany2.pdf

β-Amyloid(1-42) affects cholinergic but not parvalbumin-containing neurons in the septal complex of the rat

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Proceedings - University of Groningen