A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity

Abstract

International audienceA convenient synthesis of novel N-N’-substituted 1,2,5-thiadiazolidine 1,1-dioxides starting from amino acids isreported in five step (reduction, carbamoylation-sulfamoylation, intermolecular cyclization via the Mitsunobureaction and acylation). The newly synthesized compounds were characterized by IR, NMR and mass spectralanalysis. Some of the newly synthesized compounds (4c and 4d) were examined for their antibacterial activityagainst several strains of Gram-positive and Gram-negative bacteria