HUONG Doan Thi Thanh

English

NARO Institutional Repository

Phenolic Compounds and Lipid Metabolismjournal orpublication titleReport of National Food Research Institutevolume 70page range 30-30year 2006-03-01URL http://doi.org/10.24514/00002689doi: 10.24514/00002689 30 Phenolic Compounds and Lipid Metabolism Doan Thi Thanh Huong UNU-Kirin Fellow from Vietnam Nutritional Biochemistry Laboratory, National Food Research Institute The effects of natural phenolic compounds including naringenin, hesperetin, and isoflavone as well as a non phenolic com­pound, lipoic acid, in affecting hepatic fatty acid metabolism were examined in mice and rats. In the first experiment, mice were fed experiment diets containing either 1% naringenin, 1% hesperetin, 2% soy isoflavone or 1% lipoic acid for 21 d. Diets con­taining naringenin and lipoic acid increased the activity and gene expression of various enzymes involved in fatty acid oxidation except for one occasion. The increase was greater in the latter than in the former. A diet containing a soy isoflavone preparation containing 47% isoflavones mainly as glucoside also increased some of the parameters of fatty acid oxidation. Hesperetin did not affect any of the parameters for hepatic fatty acid oxidation. Lipoic acid strongly decreased the activity and mRNA of vari­ous lipogenic enzymes. However, other compounds were rather irrelevant in affecting parameters of lipogenesis. Naringenin, isoflavone and lipoic acid, but not hesperetin reduced serum concentrations of triacylglycerol, cholesterol and phospholipid except for one occasion. In the second trial, to confirm the strong influence of lipoic acid on hepatic fatty acid metabolism, rats were fed experiment diets containing different amounts (0, 0.1, 0.25 and 0.5%) of lipoic acid for 21 d. Lipoic acid dose-depend-ently decreased the activity and mRNA levels of hepatic lipogenic enzymes accompanying great decreases in the serum concen­trations of triacylglycerol, cholesterol, phospholipid, free fatty acid and glucose. However, lipoic acid-dependent increase in hepatic fatty acid oxidation observed in mice was not necessarily confirmed in rats indicating species difference of the physio­logical activity of this compound in affecting hepatic fatty acid metabolism. Alteration of hepatic fatty acid metabolism may account for the hypolipidemic propensities of naringenin, isoflavone and lipoic acid in mice and rats. 

Phenolic Compounds and Lipid Metabolism

https://repository.naro.go.jp/?action=repository_action_common_download&item_id=2807&item_no=1&attribute_id=22&file_no=1

Phenolic Compounds and Lipid Metabolism

Abstract

Similar works

Full text

Available Versions

NARO Institutional Repository