Clear signs of climate stress on groundwater resources have been observed in recent years even in generally water-rich regions such as Germany. Severe droughts, resulting in decreased groundwater recharge, led to declining groundwater levels in many regions and even local drinking water shortages have occurred in past summers. We investigate how climate change will directly influence the groundwater resources in Germany until the year 2100. For this purpose, we use a machine learning groundwater level forecasting framework, based on Convolutional Neural Networks, which has already proven its suitability in modelling groundwater levels. We predict groundwater levels on more than 120 wells distributed over the entire area of Germany that showed strong reactions to meteorological signals in the past. The inputs are derived from the RCP8.5 scenario of six climate models, pre-selected and pre-processed by the German Meteorological Service, thus representing large parts of the range of the expected change in the next 80 years. Our models are based on precipitation and temperature and are carefully evaluated in the past and only wells with models reaching high forecasting skill scores are included in our study. We only consider natural climate change effects based on meteorological changes, while highly uncertain human factors, such as increased groundwater abstraction or irrigation effects, remain unconsidered due to a lack of reliable input data. We can show significant (p<0.05) declining groundwater levels for a large majority of the considered wells, however, at the same time we interestingly observe the opposite behaviour for a small portion of the considered locations. Further, we show mostly strong increasing variability, thus an increasing number of extreme groundwater events. The spatial patterns of all observed changes reveal stronger decreasing groundwater levels especially in the northern and eastern part of Germany, emphasizing the already existing decreasing trends in these region