The first measurements of differential branching fractions of inclusive semileptonic B → Xuℓ+νℓ decays are performed using the full Belle data set of 711 fb−1 of integrated luminosity at the Υ(4S) resonance and for ℓ=e, μ. With the availability of these measurements, new avenues for future shape-function model-independent determinations of the Cabibbo-Kobayashi Maskawa matrix element |Vxub| can be pursued to gain new insights in the existing tension with respect to exclusive determinations. The differential branching fractions are reported as a function of the lepton energy, the four-momentum-transfer squared, light-cone momenta, the hadronic mass, and the hadronic mass squared. They are obtained by subtracting the backgrounds from semileptonic B → Xuℓ+νℓ decays and other processes, and corrected for resolution and acceptance effects