The United States has thousands of invasive species, representing a sizable, but unknown burden to the national economy. Given the potential economic repercussions of invasive species, quantifying these costs is of paramount importance both for national economies and invasion management. Here, we used a novel global database of invasion costs (InvaCost) to quantify the overall costs of invasive species in the United States across spatiotemporal, taxonomic, and socioeconomic scales. From 1960 to 2020, reported invasion costs totaled 4.52trillion(USD2017).Consideringonlyobserved,highlyreliablecosts,thistotalcostreached1.22 trillion with an average annual cost of 19.94billion/year.Thesecostsincreasedfrom2.00 billion annually between 1960 and 1969 to 21.08billionannuallybetween2010and2020.Mostcosts(73896.22 billion), as opposed to management expenditures (46.54billion).Moreover,themajorityofcostswerereportedfrominvadersfromterrestrialhabitats(643.51 billion, 53%) and agriculture was the most impacted sector (509.55billion).Fromataxonomicperspective,mammals(234.71 billion) and insects ($126.42 billion) were the taxonomic groups responsible for the greatest costs. Considering the apparent rising costs of invasions, coupled with increasing numbers of invasive species and the current lack of cost information for most known invaders, our findings provide critical information for policymakers and managers