In order to enhance the tumoricidal efficacy of the diluted Betadine® its water solutions were combined with the buffer solutions of Serratia marcescens nuclease. Examination of the combined effect on viability of cancer cells of rat hepatoma (H4-II-E-C3) in vitro showed the enhancement of a tumoricidal effectiveness of the prepared composition in comparison with the diluted Betadine® or the nuclease solutions. The Betadine® water solutions containing up to 5% of povidone-iodine were found to be compatible with Serratia marcescens nuclease solutions
