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Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice
Authors
Chikamoto Keita
Ishii Kiyoaki
+14 more
Kikuchi Akihiro
Matsugo Seiichi
Misu Hirofumi
Shiba Kazuhiro
Takamura Toshinari
Takayama Hiroaki
Tsugane Hirohiko
Yamamoto Tatsuya
御簾 博文
松郷 誠一
柴 和弘
石井 清朗
篁 俊成
菊地 晶裕
Publication date
6 August 2020
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
金沢大学疾患モデル総合研究センターLeukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that causes skeletal muscle insulin resistance. The circulating levels of LECT2 are a possible biomarker that can predict weight cycling because they reflect liver fat and precede the onset of weight loss or gain. Herein, to clarify the dynamics of this rapid change in serum LECT2 levels, we investigated the in vivo kinetics of LECT2, including its plasma half-life and tissue distribution, by injecting 125I-labelled LECT2 into ICR mice and radioactivity tracing. The injected LECT2 was eliminated from the bloodstream within 10 min (approximate half-life, 5 min). In the kidneys, the radioactivity accumulated within 10 min after injection and declined thereafter. Conversely, the radioactivity in urine increased after 30 min of injection, indicating that LECT2 is mainly excreted by the kidneys into the urine. Finally, LECT2 accumulated in the skeletal muscle and liver until 30 min and 2 min after injection, respectively. LECT2 accumulation was not observed in the adipose tissue. These findings are in agreement with LECT2 action on the skeletal muscle. The present study indicates that LECT2 is a rapid-turnover protein, which renders the circulating level of LECT2 a useful rapid-response biomarker to predict body weight alterations. © 2020, The Author(s).CC-BY 4.
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Last time updated on 28/06/2022