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Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma
Authors
Endo Kazuhira
Kitagawa Noriko
+7 more
Kondo Satoru
Murono Shigeyuki
Nakanishi Yosuke
Tsuji Akira
Wakisaka Naohiro
Yoshizaki Tomokazu
Zen Yoh
Publication date
30 April 2013
Publisher
'Elsevier BV'
Doi
Cite
Abstract
Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis. © 2012 Elsevier Ireland Ltd
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Last time updated on 06/05/2019