We investigated the effectiveness of the ClearSight system for hemodynamic management during kidney transplantation for a recipient. The recipient was to receive a kidney transplant from his mother under general anesthesia.We used continuous noninvasive finger-cuff-based monitoring of blood pressure, provided by the ClearSight system, and stroke volume variation to predict fluid responsiveness. We used of a balanced anesthetic technique and stringent monitoring standards to ensure a successful outcome for the patient. This case demonstrated that ClearSight has the potential to improve patient monitoring in hemodynamically stable patients who received kidney transplantation under general anesthesia

Kakuta, Nami

Kasai, Asuka

Kume, Katsuyoshi

Murakami, Chiaki

Oyama, Takuro

Sakai, Yoko

Tanaka, Katsuya

Tsutsumi, Yasuo M.

Tokushima University Institutional Repository

INTRODUCTIONRenal transplantation is important for hemodynamic manage-ment and fluid volume control (1). We usually use continuoushemodynamic monitoring, arterial line (A- line) and central venouscatheter (CVC), as a guide fluid management and to adjust inotropicand/or vasopressor agents. However, both A-line and CVC re-quire invasive catheters.The ClearSight system (Edwards Lifesciences Cop, Irvine, CA,USA) is a device used for measuring arterial blood pressure con-tinuously and noninvasively through finger- cuffed technology (2).Not only finger-cuff -based monitoring of blood pressure (FBP),but the ClearSight system provide heart rate (HR), stroke volume(SV), cardiac output (CO), cardiac index (CI), stroke volume index(SVI), stroke volume variation (SVV), systemic vascular resistance(SVR), and systemic vascular resistance index (SVRI) (3). It isnoninvasive measurement.Therefore, we investigated the ClearSight system may be useful-ness in renal transplantation recipient as a reliable and totallynoninvasive method of fluid measurement without CVC.CASE REPORTThe recipient of the renal transplantation in this study was a 41-year-old male, with a weight of 91.2 kg and height of 163.5 cm withend-stage renal failure. He had a history of multicystic renal cyst,multicystic liver cyst, and hypertension. His routine blood reportswere normal, except for renal dysfunction (BUN 36.3 mg/dl, Cr7.29 mg/dl). The patient’s electrocardiogram (ECG) showed a soli-tary T- wave inversion in III. The chest X-ray was normal. Hisechocardiography report showed that he had a functional leftventricle with an ejection fraction of 75%, mild left ventricular (LV)hypertrophy, and LV diastolic dysfunction, and not reduced car-diac function. He started hemodialysis in November 2016 from adistal radiocephalic arteriovenous fistula (AVF) on the left arm.Because of the symptoms of nausea and vomiting, the patientexperienced after every hemodialysis, treatment was short-ened. It was determined that he could receive renal transplantfrom his mother, under general anesthesia. His intravenous accesswas established using an 18-G cannula on the right hand. After aradial artery was cannulated (A-line), the figure cuff of the ClearSightdevice (Edwards Lifesciences Cop, Irvine, CA, USA) was placedaround the patient’s right hand index finger. Pulse oximetry, ECG,non- invasive blood pressure (NBP), end tidal CO2, core body tem-perature by a rectum probe, hourly urine output, and finger-cuff -based monitoring of blood pressure (FBP), cardiac output (CO),stroke volume variation (SVV) were measured.Anesthesia was induced with DIV remifentanil 0.3 µg/kg/ minand IV propofol 1 mg/kg. Intubation was facilitated with IV rocu-ronium 60 mg. Anesthesia was maintained with sevoflurane, O2,air, and rocuronium as the muscle relaxant, in combination withremifentanil 0.1 -0.3 µg/ kg/ min and fentanyl. We managed thefluid volume with SVV obtained with the ClearSight to predict fluidresponsiveness. Stroke volume variation may be a useful pa-rameter to predict hypovolemia and fluid responsiveness duringrenal transplantation (3).Until clamping the renal artery, the infusion volume is themaintenance volume and the bleeding volume. We maintainedFBP 90/55 mmHg, heart rate (HR) 60 bpm, SVV 12%, stroke volume(SV) 86mL/b and CO 5.2 L/min. As SVV is modified by lung compli-ance and ventilatory management, we setted ventilatory control totidal volume 600 mL, positive end-expiratory pressure 0 mmHg,and peak airway pressure 18mmHg. We usually managed, beforedeclamping the renal artery, a central venous pressure (CVP) of12 - 15 mmHg were ensured with the help of generous hydration. InCASE REPORTEffectiveness of using non-invasive continuous arterialpressure monitoring with ClearSight in hemodynamicmonitoring during living renal transplantation in arecipient : a case reportNami Kakuta, Yasuo M. Tsutsumi, Chiaki Murakami, Yoko Sakai, Takuro Oyama, Asuka Kasai, Katsuyoshi Kume, andKatsuya TanakaDepartment of Anesthesiology, Tokushima University 3-18-15 Kuramoto, Tokushima, 770-8503, JapanAbstract : We investigated the effectiveness of the ClearSight system for hemodynamic management duringkidney transplantation for a recipient. The recipient was to receive a kidney transplant from his mother undergeneral anesthesia. We used continuous noninvasive finger-cuff-basedmonitoring of blood pressure, providedby the ClearSight system, and stroke volume variation to predict fluid responsiveness. We used of a balancedanesthetic technique and stringent monitoring standards to ensure a successful outcome for the patient. Thiscase demonstrated that ClearSight has the potential to improve patient monitoring in hemodynamically stablepatients who received kidney transplantation under general anesthesia. J. Med. Invest. 65 : 139-141, February,2018Keywords : ClearSight system, finger cuff, noninvasive, renal transplant recipientReceived for publication September 6, 2017 ; accepted October 13, 2017.Address correspondence and reprint requests to Nami Kakuta, M.D.,Ph.D. Department of Anesthesiology, Tokushima University 3 -18 -15,Kuramoto, Tokushima 770-8503, Japan and Fax : +81-88 -633-7182.The Journal of Medical Investigation Vol. 65 2018139this case, CVC was not inserted, we defined systolic FBP as beingmaintained above 120 mmHg and SVV of 4-6% of increasing SV andCO, instead of CVP. This volume expansion is associated with in-creased renal blood flow and improved graft function. Just beforeanastomosis and clamp release, we decreased the SVV by 4% (abso-lute percentage value), increased SV and CO, and maintainedFBP to provide adequate perfusion to the transplanted kidney. Wemaintained FBP at 120-136/65-70 mmHg, HR 68-76 bpm, SVV 4-6%, SV 106-120 mL/b and CO 7.2-9.7 L/min. Furosemide wasgiven to improve graft viability and ensure diuresis. The patient’ssystolic FBP was kept above 120 mmHg until the end of the sur-gery, and about 3000 mL of crystalloids and 100 mL of colloids(20% human serum albumin) were infused. There was adequateurine output of 900 mL per hour after reperfusion. The patient wasextubated uneventfully, after complete reversal of muscle paraly-sis. We made use of a balanced anesthetic technique and stringentmonitoring standards to ensure a successful outcome for the pa-tient. On the 11 postoperative day, the patient went home with ahealthy functioning kidney (BUN 35.7 mg/dl, Cr 2.45 mg/dl).DISCUSSIONRenal transplantation is important for hemodynamic manage-ment and fluid volume control. Our goals for perioperative manage-ment were to maintain stable hemodynamics throughout the pro-cedure, perform adequate infusion, maintain perfusion for thetransplanted solitary kidney, and to provide adequate analgesia forthe patient. Therefore, continuous hemodynamic monitoring, A-line and CVC, is of use as a guide fluid management and to adjustinotropic and/or vasopressor agents. However, both A-line andCVC require invasive catheters and therefore increase the risk ofcatheter infection, bleeding, deep venous thrombosis, and pneu-mothorax (2).The ClearSight system uses photoplethysmography and an in-flatable cuff placed around a finger (Figure 1). This measures fin-ger arterial pressure directly from the finger cuff using a volume-clamp method, from which brachial arterial pressure is recon-structed using waveform filtering with pressure level correction(4). The ClearSight system provide continuous noninvasive FBP,HR, SV, CO, cardiac index (CI), stroke volume index (SVI), SVV,systemic vascular resistance (SVR), and systemic vascular resis-tance index (SVRI). Stroke volume is estimated based on arterialpressure waveforms obtained from the finger artery, and multi-plied by the pulse to express CO (3). Respiration-related changes inthe SV (SVV) are serially expressed. Stroke volume variation maybecome a parameter of optimized hemodynamics and fluid respon-siveness (3).Fig 2. Vital record with ClearSight. First arrow shows the renal artery clamped. Second arrow is the renal artery declamped.SBP = systolic blood pressure, mmHg. SV = stroke volume, mL/b. MAP = mean arterial pressure, mmHg. DBP = diastolic blood pressure,mmHg. PR = pulse rate, bpm. SVV = stroke volume variation, %. CO = cardiac output, L/min.Fig 1. The ClearSight device140 N. Kakuta, et al. ClearSight and renal transplant recipientOur main goal during the renal transplantation, to promote thefunction of the transplanted kidney and maintain an adequate vol-ume of blood flow in the transplanted kidney to prevent acutetubular necrosis(5). Therefore, before clamping the renal artery, wemanaged a normal FBP and a SVV of 10-13% using the ClearSightsystem. After declamping, the kidney was perfused, maintained at ahigh normal FBP and co-hydration to maintain kidney bloodflow, to get urine volume, SVV decreased by 4-6% (absolute per-centage value). Although we used SVV to fluid volume control, itshould be management from correlation between SVV and SVI.Further research is needed to determine whether this manage-ment (SVV of 4-6% of increasing SV and CO) is optimal to preventthe postoperative acute tubular necrosis.The accuracy of FBP compared with NBP and invasive bloodpressure was not inferior in this case. The bias between ClearSightwas less than 5 mmHg with NBP and ABP. However, Hohn evalu-ated non- invasive continuous arterial pressure monitoring did notsufficiently replace invasive measurements in critically ill patients(6). In their study, critically ill patients experienced edema and hadcontinuous norepinephrine administration that may have reducedperipheral blood flow, affecting the non- invasive measurements.Our patient had adequate cardiac function and was not in thecritically ill state, ClearSight was a reliable monitor, but, furtherstudy is needed using various patients.In fully sedated and mechanically ventilated patients, SVV can beconsidered as a reliable monitor of fluid responsiveness(2). Strokevolume variation is the most reliable predictor of optimized hemo-dynamics and fluid responsiveness, many studies have reported itsaccuracy (7-9). In this case, we did not fhe CVC to reduce invasivecatheters. It might be more better to compare SVV and CVP. Itwould have been interesting to know how the SVV-guided fluidmanagement affected CVP (10).Recent studies have shown the feasibility of noninvasive and con-tinuous blood pressure measurements during surgical proce-dures. However, accuracy and precision are still debated (11). Thiscase demonstrated ClearSight has potential to improve patientmonitoring in hemodynamically stable patients who receive kidneytransplantation under general anesthesia.However, further studiesare needed to provide reliable information for the intraoperativemanagement of high risk patients during renal transplantationwithout the need for invasive arterial cannulation and centralvenousr catheter.In addition, we have used the ClearSight in living renal trans-plantation. We think that it is also useful in cadaveric renal trans-plantations. Transfusion management of cadaveric renal transplan-tation is more difficult than living renal transplantation. Becauseoliguria often continues even after surgery, it does not load infusioneasily (12). We also want to evaluate the effectiveness of theClearSight device in cadaveric renal transplantations.CONCLUSIONClearSight is a less- invasive circulatory monitoring system thatmay improve the safety of anesthetic management during renaltransplantation. Further research, with the use of the ClearSightdevice, in renal transplantation will help to determine the safety andefficacy.CONSENT FOR PUBLICATIONFor publication of this report, written consent was obtained frompatient.COMPETING INTERESTSThe authors declare that they have no competing interests.REFERENCES1. Baker J, Yost SC, Niemann UC : Miller’s anesthesia. 6th ed.Philadelphia : Churchill Livingstone ; Organ transplantation ;pp. 2240-2241, 20052. Ameloot K, Palmers PJ, Malbrain MK : The accuracy of nonin-vasive cardiac output and pressure measurements with fingercuff : a concise review. Curr Opin Crit Care 21 : 232-9, 20153. Soga T, Kawahito S, Oi R, Kakuta N, Katayama T, WakamatsuN, et al : Recent less- invasive circulatory monitoring duringrenal transplantation. J Med Invest 60 : 159-63, 20134. Sng BL, Wang H, Assam PN, Sia AT : Assessment of an up-dated double-vasopressor automated system using Nexfinfor the maintenance of haemodynamic stability to improveperi -operative outcome during spinal anaesthesia for caesar-ean section. Anaesthesia 70 : 691-8, 20155. SarinKapoor H, Kaur R, Kaur H : Anaesthesia for renal trans-plant surgery. Acta Anaesthesiol Scand 51 : 1354-67, 20076. Hohn A, Defosse JM, Becker S, Steffen C, Wappler F, SakkaSG : Non-invasive continuous arterial pressure monitoringwith Nexfin does not sufficiently replace invasive measure-ments in critically ill patients. Br J Anaesth 111 : 178-84, 20137. Biais M, Nouette-Gaulain K, Cottenceau V, Revel P, Sztark F :Uncalibrated pulse contourderived stroke volume variationpredicts fluid responsiveness in mechanically ventilated patientsundergoing liver transplantation. Br J Anaesth 101 : 761-8,20088. Cannesson M, Musard H, Desebbe O, Boucau C, Simon R,Henaine R, et al : The ability of stroke volume variations ob-tained with Vigileo/FloTrac system to monitor fluid respon-siveness in mechanically ventilated patients. Anesth Analg108 : 513-7, 20099. Slagt C, Malagon I, Groeneveld AB : Systematic review ofuncalibrated arterial pressure waveform analysis to deter-mine cardiac output and stroke volume variation. Br J Anaesth112 : 626-37, 201410. Ferris RL, Kittur DS, Wilasrusmee C : Early hemodynamicchanges after renal transplantation : determinants of lowCVP in the recipients and correlation with acute renal dysfunc-tion. Med Sci Monit 9 : 61-66, 200311. Martina JR, Westerhof BE, van Goudoever J, de BeaumontEM, Truijen J, Kim US, et al : Noninvasive continuous arterialblood pressure monitoring with Nexfin. Anesthesiology116 : 1092-103, 201212. Potura E, Lindner G, Biesenbach P, Funk GC, Reiterer C,Kabon B, et al : An acetate-buffered balanced crystalloidversus 0.9% saline in patients with end-stage renal disease un-dergoing cadaveric renal transplantation : a prospective ran-domized controlled trial. Anesth Analg 120 : 123-9, 2015The Journal of Medical Investigation Vol. 65 February 2018 141

Effectiveness of using non-invasive continuous arterial pressure monitoring with ClearSight in hemodynamic monitoring during living renal transplantation in a recipient : a case report

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Effectiveness of using non-invasive continuous arterial pressure monitoring with ClearSight in hemodynamic monitoring during living renal transplantation in a recipient : a case report

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